Dr. Christopher Browning, Sociology
Rank at time of award: Professor
and
Dr. Baldwin Way, Psychology
Rank at time of award: Associate Professor
and
Dr. Jodi Ford, Nursing
Rank at time of award: Professor
and
Dr. Bethany Boettner, Institute for Population Research
Rank at time of award: Research Scientist
Racial disparities in cardiovascular disease (CVD) are an ongoing public health concern. Evidence indicates that racial disparities in key CVD risk factors such as sleep quality, physical activity, inflammation, and hypertension are influenced by racial differences in adverse sociospatial exposures (e.g., disadvantaged neighborhoods) and emerge early in the life course. Rich data linking contextual stressors to adolescent health outcomes is limited and insufficient for robust examination of the mechanisms through which spatial contexts (neighborhoods and everyday activity spaces) contribute to racial disparities in CVD risk. The purpose of this proposed seed grant is to pilot test the integration of data collection on CVD-relevant measures of sleep, physical activity, and inflammatory markers into the protocol of an existing study design, which was recently favorably reviewed by NIH. Preliminary data from the pilot on the additional measures will be incorporated into a supplementary R01 proposal to NICHD to investigate activity space associations with adolescent CVD risk. Specifically, proposed seed grant-supported tasks are as follows:
(1) recruitment of 40 youths (25 Black youth and 15 white youth) between ages 13 and 17 from the east side of Columbus to participate in a two-month pilot;
(2) consent youth to (a) carry a project provided iPhone for 2 months involving ecological momentary assessment administration and continuous GPS tracking, (b) wear a wrist-borne device for continuous monitoring of sleep and physical activity. and (c) provide a saliva sample and dried blood spot once every two weeks (five measures total) for validation of salivary interleukin-6;
(3) monitor compliance with the study protocol: (a) do youth continuously wear the wrist-borne device (i.e., during both daytime and nighttime hours) to ensure capture of physical activity and sleep data? and (b) monitor EMA response rates globally and on proposed additional sleep questions to assess feasibility of collecting integrated objective/subjective sleep quality data in addition to the baseline EMA administration schedule;
and (4) conduct analyses for preliminary data to be included in adolescent CVD risk R01 application.
These pilot data will substantially enhance the rigor of the proposed R01 application examining adolescent CVD risk and support any additional submissions based on the currently pending grant.